TisXell Bioreactor

Accelerating Cells and Tissue Development with Quality and Quantity

Why TisXell?

TisXell is a next-generation bioreactor system designed to revolutionize cell and tissue development through patented biaxial rotation with perfusion technology. Built for researchers, clinicians, and engineers, TisXell replicates in vivo-like conditions in vitro, promoting faster, healthier, and more uniform cell growth.

Key Benefits

Simulates native extracellular matrix (ECM) with optimized shear and flow conditions.
Achieves homogeneous cell proliferation at both surface and deep scaffold cores.
Maintains high viability with reduced necrotic zones and minimal cell debris.
No adverse effects on mRNA expression levels related to cell lineage or stemness.
Shown to enhance osteogenesis and chondrogenesis in multiple studies.

Applications

Cell Therapy

  • Expansion of B & T Lymphocytes, CAR-T, and MSCs
  • Single-batch expansion using microcarriers
  • Clinically relevant scale and sterility

Drug Development

  • Supports long-term toxicity testing
  • Enables high-fidelity disease modeling using spheroids and organoids

Biomaterials Testing

  • Improves biochemical and mechanical outcomes of engineered cartilage
  • Aids in selecting and remodeling biomaterials

Tissue Engineering

  • Efficient mass transfer in thick grafts
  • Shorter culture time with improved ECM
  • Applications in bone, cartilage, and vascular tissue engineering

How It Works

The biaxial rotating mechanism involves two independent orthogonal axes (spin and tumble) within a spherical vessel design. This promotes:
  • Low-shear, uniform fluid mixing
  • Optimal nutrient and gas exchange
  • Mechanotransduction signaling for tissue remodeling
Customizable holders, scaffold supports, and chamber sizes available.

Proven Performance

  • Up to 10x Cell Expansion compared to static chambers
  • Healthy Cell Morphology with less clumping and debris
  • Retained Chondrogenic Markers: Higher expression of Col2 and Agg, confirming native function
  • Scalability: From 25 ml to 2000 ml with multiple configurations (TX and MX models)